Tuesday, October 15, 2019

Transplant Tourism: Ethics in Organ Procurement


(Review of Broumand & Saidi, 2017 and The Transplantation Society's "Policy & Ethics")

While kidneys are usually thought of as the only organ that can be donated by a living donor, living donors can actually donate portions of the lungs, liver, pancreas, and intestine (The Transplantation Society). A living donor can function with only 1 kidney, the donated portion of the liver regenerates, and donated non-regenerative portions of the liver, pancreas, and intestine are not required for full bodily functioning, although donors may have certain physiological limits in terms of exercise (Health Services and Resources Administration).

Though increased live organ transplantation helps alleviate the long waiting list for cadaver organs, this avenue presents its own host of ethical problems. “Transplant tourism” occurs when individuals from developed countries with long waiting lists for organs travel to underdeveloped countries where there is little regulation prohibiting the sale of organs and where there are economically disadvantaged individuals willing to sell body parts to support themselves (Broumand & Saidi, 2017). This creates the potential for live donor transplantation to become an economically abused enterprise.

The Transplantation Society (an NGO with official relations with the World Health Organization) asserts that living donors must be of sound mind, must not be coerced, must be informed of the potential risks involved, and must be informed of alternative treatments available to the recipient (among others), and states that, “organs and tissues should be freely given without commercial consideration or financial profit” (The Transplantation Society). However, these are policies established by this society at select transplantation conferences and there is no international regulatory body that oversees organ xenotransplantation. Transplant tourism has thus become problematic due to the lack of regulation and the potential for exploitation of donors and recipients (The Transplantation Society).

Justice and autonomy are central to transplant tourism via the involvement of multiple parties. How do these ethical factors play out if a wealthy individual can travel to another country to pay for a liver part from a live donor who has been coerced by their family to donate so that they can pay their bills? What if the individual is perfectly willing to donate an organ (and of sound mind) in order to provide for their family?

            
The Transplantation Society also condemns harvesting organs from executed prisoners. This could constitute an entirely new blog thread, but is a relevant and horrifying ethical dilemma considering recent allegations that the Chinese government is detaining and harvesting the organs of ethnic minorities (Withnall, 2019, September 24). “Where there is demand, there is supply” can have dark implications for all 4 of the biomedical ethical principles when medicine and economics are mixed.

Cited Literature

Broumand, B., & Saidi, R. F. (2017). New Definition of Transplant Tourism. Int J Organ Transplant Med, 8(1), 49-51.
Health Services and Resources Administration. The living donation process.   Retrieved from https://www.organdonor.gov/about/process/living-donation.html
The Transplantation Society. Policy & ethics.   Retrieved from https://www.tts.org/index.php?option=com_content&view=article&id=11&Itemid=223
Withnall, A. (2019, September 24). China is killing religious and ethnic minorities and harvesting their organs, un human rights council told.   Retrieved from https://www.independent.co.uk/news/world/asia/china-religious-ethnic-minorities-uighur-muslim-harvest-organs-un-human-rights-a9117911.html

1 comment:

  1. Alex, You’re post immediately interested me. I am strongly against transplant tourism. I believe it is highly unethical to travel to another country to pay for an organ and taking advantage of the individuals in underdeveloped countries. It violates the biomedical principle of non-maleficence as you are doing harm to the individual by removing part of their organ through bribery of money. One potential way to combat this is to only allow individuals to receive organs within countries that they can prove they have been living in for six months. Another potential solution would be to educate the general public on being living donors and the need many people have for organs. This may increase the number of organs available to be transplanted. Instead of coercing people with money, they will instead be donating out of the goodness of their heart. I have a 15-year old cousin who will be receiving a kidney transplant within the next year or two due to damaged kidneys that are progressively becoming less functional as a result of vesicoureteral reflux when he was born. Because of this, our family is often discussing and researching kidney transplants. He will be receiving a kidney from his dad, but while conducting research I learned about a bioartificial kidney. The bioartificial kidney was recently (November 2019) implanted into large animals with the goal of eliminating the need for dialysis or a transplant from a human donor (Weiler, 2019). It contains cultured human kidney cells as well as a hemofilter (Weiler, 2019). The hemofilter will act to filter blood and remove waste, while the kidney cells can produce hormones and maintain appropriate blood pressure (Weiler, 2019). One of the major pro’s is it eliminates the need for anti-rejection drugs as there is no immune response (Weiler, 2019). I am very excited to see how this bioartificial kidney will develop and function in the future, and I was thinking this may be a potential solution in the distant future to many organ transplant procedures. It will take time before an artificial organ can be inserted and function, but I think this has the potential for a very promising outcome.

    Weiler, N. (2019). Implantable bioartificial kidney achieves preclinical milestone | School of Pharmacy | UCSF. Retrieved December 6, 2019, from https://pharmacy.ucsf.edu/news/2019/11/implantable-bioartificial-kidney-achieves-preclinical-milestone

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